If Not Warfarin Why Not Aspirin?

Ask "WHY NOT?" Not "WHAT IF?"

The editor-in-chief asks: with strong evidence in favour of collaborative practice, why has it not yet been adopted across the system? What is holding it back?

Why do patients with atrial fibrillation not receive warfarin?

Atrial fibrillation (AF) is a growing public health problem associated with significant morbidity and mortality. Numerous randomized controlled trials of warfarin have conclusively demonstrated that long-term anticoagulation therapy can reduce the risk for stroke by approximately 68% per year in patients with nonvalvular AF, and even more in patients with valvular AF. However, available data sh...

Warfarin therapy--why one dose does not fit all!

We report an Indian adult female patient with Deep Vein Thrombosis (DVT), in whom it was difficult to achieve and maintain target INR on warfarin (oral anticoagulant) by conventional doses. Pharmacogenomics study for warfarin revealed that she had Homozygous mutant for CYP2C9 *3(CYP2C9 *3/*3) and Heterozygous mutant for VKORC 1(1639G >A) {genetic polymorphism double defect}. This conferred a gr...

Not if but when; no longer why but how

There is accruing evidence that information technology can improve patient health care, with several trials of technology showing smaller numbers of medication errors, or can provide earlier detection of adverse events. Critics of this type of research point out that better resolution of events is of no value unless their direct management influences clinical outcome. Nevertheless, indirect evi...

"If not us, who? If not now, when?".